Like its companion on the opposite side of the room, this marble sarcophagus is a work of Roman art from the 2nd century AD, and is one of the tombs that were reused in the Middle Ages as prestigious burials, characterizing the cemetery area around the Cathedral and the Baptistery. Over the centuries, this sarcophagus and its historical pair were placed in various locations: for a time, they were housed inside the Cathedral, then mounted on large corbels on the façade of the nearby Compagnia dei Laudesi, and later, in the 19th century, exhibited in the courtyard of Palazzo Medici Riccardi. After a century, they were moved to the sides of the South Door of the Baptistery, where they were struck by the waters of the 1966 flood (at which time this one lost its roof-shaped lid). In 1998, they found refuge in the Museum.

In the two side aedicules are depicted the two spouses who owned the tomb: she, to the left of the viewer, is veiled and accompanied by a peacock and a flower at her feet—both symbolic attributes. He stands to the right, bald, elderly, and wearing a toga; beside him is their son, and below, a set of scrolls on a casket likely alludes to his profession—possibly as an intellectual or scholar. The central portal is flanked by two Victories and two personifications of favorable Fortune; in the tympanum sits an eagle, symbol of eternity. From the central doorway, representing the entrance to the Underworld, the psychopomp god Mercury peeks out, wearing his winged petasos cap. On either side of the portal stand two “Karibu” monsters—winged lions with bull horns—guardians of the dead.